Resident Editor: Patrick Azcarate, MD
Faculty Editor: Elisabeth Askin, MD
Drug |
Recommended dosing frequency |
Sample dose equivalency |
Maximum total daily dose |
Dose reduction |
---|---|---|---|---|
Beta-1 Selective |
|
|||
Acebutolol |
BID |
100mg BID |
1,200mg |
CrCl <50 |
Atenolol |
Daily |
50mg Daily |
100mg |
CrCl <35 |
Bisoprolol |
Daily |
5mg Daily |
20mg |
CrCl <40, cirrhosis, heart failure (10mg total daily) |
Metoprolol IR |
BID |
50mg BID |
400mg |
Heart failure (200mg total daily) |
Metoprolol SR |
Daily |
100mg Daily |
||
Non-Selective |
|
|||
Carvedilol IR |
BID |
12.5mg BID |
100mg |
Weight <85kg, heart failure (50mg total daily), Contraindicated in severe liver impairment |
Carvedilol ER |
BID |
40mg daily |
80mg |
|
Labetalol |
BID-TID |
100mg BID |
2400mg |
|
Nadolol |
Daily |
80mg Daily |
320mg |
CrCl <50 |
Pindolol |
BID |
5mg BID |
60mg |
Liver impairment |
Propranolol IR |
BID |
40mg BID |
640mg |
Liver impairment |
Propranolol ER |
Daily |
80mg Daily |
||
Sotalol |
BID |
80mg BID |
320mg |
CrCl <60 |
Timolol |
BID |
5mg BID |
60mg |
|
*Disclaimer: These are not typical starting doses. Recommended starting doses depend on the clinical scenario.
Reference:
Pham P. Beta-blockers. Johns Hopkins Guides. September 26, 2013. Available
http://www.globalrph.com/beta_blockers.htm
Yancy 2013
Micromedex Comparison Tables: Beta Blockers. Last Modified: May 11, 2016.
Lexi-Comp, Inc. (Lexi-Drugs). Lexi-Comp, Inc.; April 10, 2018.