Resident Editor: Carine Davila, MD
Faculty Editor: Elisabeth Askin, MD
|
Drug |
Recommended dosing frequency |
Starting dose |
Approximate dose equivalence |
Usual maintenance dose |
Maximum dose |
|---|---|---|---|---|---|
|
Benazepril |
Daily or two divided doses |
10mg (5mg if pt on diuretic) |
10 mg |
20-40 mg |
80mg/day |
|
Captopril |
BID (HTN) TID (HF) |
25mg (HTN) 6.25 mg (HF) |
12.5 mg |
50-100 mg/day |
200mg/day HTN) 150mg/day (HF) |
|
Enalapril |
Daily (HTN) BID (HF) |
5mg (HTN) 2.5 mg (HF) |
5 mg |
10-40mg (HTN) 2.5-20 mg (HF) |
40mg/day |
|
Lisinopril |
Daily |
10mg (HTN) 5 mg (HF) |
10 mg |
20-40 mg |
40mg/day |
|
Ramipril |
Daily |
1.25-2.5mg |
2.5 mg |
2.5-10mg |
20mg/day (HTN) 10mg/day (HF) |
- Disclaimer: Starting doses and titration schedule depend on individual clinical scenario and are particularly important to review with renal failure that may have different starting dose recommendations*.
- In addition to the above, there are some less commonly used ACEi that are listed here with their dose equivalence:
- Fosinopril: 10mg
- Moexipril: 7.5mg
- Perindopril: 4mg
- Quinapril: 10mg
- Trandolapril: 1mg
Reference:
Greater Rochester Independent Practice Association. Approximate Dose Conversions. http://gripa.org/member-services-care-management-pharmacy-tidbits.asp. October 2006. Accessed October 5, 2014.
Yancy et al. 2017 ACC/AHA/HFSA Heart Failure Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure. Circulation. http://circ.ahajournals.org/content/circulationaha/early/2017/04/26/CIR.0000000000000509.full.pdf. Accessed April 15, 2018.
UNC Center for Excellence in Chronic Illness Care. https://www.med.unc.edu/im/files/enhanced-care-files/HTN_Protocol_6.05.pdf. Accessed April 15, 2018.
Micromedex. Individual Drugs. Accessed May 29, 2018.